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June 2005

Features

Cover Story

Payers’ Costly Battle Against Cancer

With better drugs, many cancers are becoming chronic diseases necessitating costly maintenance, and insurers are scrambling for ways to control their expenditures. Early efforts to rein in costs are being met with stiff resistance from oncologists, however.
Chuck Appleby
PDF

Industry

Will Combinatorial Chemistry Keep its Promise?

Once the hottest of new technologies, this didn’t live up to its initial promise. Now, biotechs are refining the science to develop targeted libraries and important new therapies.
John Carroll
PDF

Formularies

Expect P&T Committees to Demand More Data

Recent withdrawals of popular therapies will have multiple effects. At managed care plans, formulary committees are likely to demand more postmarketing data before embracing the next breakthrough.
Scott Kober
PDF

Clinical

Biotech Takes on The Obesity Challenge

Big pharma’s search for effective obesity treatments has proven harder than expected. Biotech is eager to step into the breach with new ideas.
Ed Silverman
PDF

Business

Starting a Biotech Company in a Dot.Com World

An entrepreneur shares lessons from his arduous search for attention from a VC crowd that was far more interested in dot.com startups than biotechs.
Bruce Y. Lee, MD, MBA
PDF

Leading Edge

The Future of Gene Therapy

Be patient and it will come, say some of the nation’s top experts in this once-promising field. Early hype was followed by setbacks – but with a cautious approach, this could become a staple of 21st century medicine.
Jack McCain
PDF

Departments

Openers

Not Your Father’s $6 Million Man

A new Steve Austin... so what?
Michael D. Dalzell
PDF

Editorial

Reviewing the Reviews

David B. Nash, MD, MBA, assesses the state of systematic reviews.
David B. Nash, MD, MBA
PDF

Discourse

The New Emphasis on Safety

What’s behind the FDA’s new emphasis on safety?
John Carroll
PDF

Drugs and Diagnostics

New Vaccine-Making Technology Shot in Arm for Industry

Genetic engineering gives birth to improved vaccine-making technology.
Bob Carlson
PDF

Biotech Business

Pharmacogenomics: Answer to Biotech’s Problems?

Pharmacogenomics is driving essential changes in drug development.
Amanda Brower
PDF

In the Pipeline

Number of Monoclonal Antibodies on Market Nearly Doubles by 2008

The Tufts Center for the Study of Drug Development projects that by 2008, the U.S. Food and Drug Administration is likely to approve 11 of the current mAb products in the pipeline.
Amanda Brower
PDF